Check Intently (1)mitotane decreases amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a robust inducer of cytochrome P-4503A4; keep track of when coadministered with CYP3A4 substrates for feasible dosage changes.Opioids The concomitant utilization of benzodiazepines and opioids improves